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The problem of determination of cause of laboratory animal's death: a critical review of definitions of "fatal" and "incidental" lesionsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 апреля 2015 г.
- Автор: Manskikh V.N.
- Журнал: Biochemistry (Moscow)
- Том: 79
- Номер: 10
- Год издания: 2014
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1075
- Последняя страница: 1080
- DOI: 10.1134/S0006297914100095
- Аннотация: The determination of the cause of a laboratory animal's death in gerontological experiments has become extraordinarily urgent in connection with the appearance of ideas on the programmed death of organisms. Unfortunately, the past approach to diagnosis of fatal and incidental changes based only on data of autopsy and histopathology (according to the human pathology model) is not correct for laboratory rodents. Nevertheless, the exact determination of death causes is principally possible in the future under conditions of adequate experimental design (including a large set of clinical, physiological, biochemical, and morphological examinations). However, it seems that even in this case causes of some experimental animal's death will remain unclear.
- Добавил в систему: Фенюк Борис Александрович