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Cytochrome bd protects bacteria against oxidative and nitrosative stress: a potential target for next-generation antimicrobial agentsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 июня 2015 г.
- Авторы: Borisov V.B., Forte E., Siletsky S.A., Arese M., Davletshin A.I., Sarti P., Giuffre A.
- Журнал: Biochemistry (Moscow)
- Том: 80
- Номер: 5
- Год издания: 2015
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 565
- Последняя страница: 575
- DOI: 10.1134/S0006297915050077
- Аннотация: Cytochrome bd is a terminal quinol oxidase of bacterial respiratory chain. This tri-heme integral membrane protein generates a proton motive force at lower efficiency as compared to heme-copper oxidases. This notwithstanding, under unfavorable growth conditions bacteria often use cytochrome bd in place of heme-copper enzymes as the main terminal oxidase. This is the case for several pathogenic and opportunistic bacteria during host colonization. This review summarizes recent data on the contribution of cytochrome bd to bacterial resistance to hydrogen peroxide, nitric oxide and peroxynitrite, harmful species produced by the host as part of the immune response to microbial infections. Growing evidence supports the hypothesis that bd-type oxidases contribute to bacterial virulence by promoting microbial survival under oxidative and nitrosative stress conditions. For these reasons cytochrome bd represents a protein target for the development of next-generation antimicrobials.
- Добавил в систему: Борисов Виталий Борисович