Место издания:https://www.msacl.org/view_abstract/MSACL_2017_EU.php?id=210
Аннотация:A summary of the author’s approaches for investigation of the mass spectral behavior of some chemical
warfare agents (CWAs), their degradation products and metabolites, as well as the results of development
of analytical methods for confirmation of nerve and blister agents application in biomedical samples are
presented. Hydrolysis and oxidation metabolites of nerve agents, sulfur mustard and lewisite were used
as biomarkers of the exposure. Sensitive analytical methods have been developed for their detection,
based mainly on tandem mass spectrometry coupled with liquid chromatography. Several techniques for
fast screening of CWAs degradation products based on capillary electrophoresis were also proposed.
Some of developed approaches were successfully applied in the frame of the proficiency testing system
of the Organization for the Prohibition of Chemical Weapons.