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Adamantane acid esters with alkoxyaryl alcohols: synthesis, antiproliferative activity, and influence on microtubule network of tumor cellsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 апреля 2018 г.
- Авторы: Zefirov N.A., Nurieva E.V., Pikulina Yu A., Ogon´kov A.V., Wobith B., Kuznetsov S.A., Zefirova O.N.
- Журнал: Russian Chemical Bulletin
- Том: 66
- Номер: 8
- Год издания: 2017
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 1503
- Последняя страница: 1509
- DOI: 10.1007/s11172-017-1915-4
- Аннотация: Adamantaneacetic and adamantanecarboxylic acid esters containing 3-hydroxy-4-methoxybenzyl, 3,4,5-trimethoxybenzyl, or 5-(hydroxymethyl)-2-methoxyphenyl groups were synthesized as unusual analogs of natural antitumor and anti-tubulin agents combretastatin A-4 and 2-methoxyestradiol. The compounds were found to possess noticeable cytotoxicity to epithelial human carcinoma cell line A549 (EC50 = 4.3—81 μmol*L–1). An ability to cause complete depolymerization of microtubule network of A549 cells was demonstrated for 5-(hydroxymethyl)-2-methoxyphenyl adamantan-1-ylacetate (6a) at a concentration of 100 μmol*L–1. Ester 6a belongs to a new structural type, which is unusual for the ligands of the tubulin colchicine domain, and is an interesting lead compound for further structural optimization.
- Добавил в систему: Евтеева Юлия Андреевна