Место издания:University of Vienna Vienna, Austria
Первая страница:74
Последняя страница:74
Аннотация:This study is focused on a novel approach to design hybrid metal-based physiollogically active compounds with dual modes of action – prooxidative activity of metal and antioxidative activity of 2,6-dialkylphenol group. The synthesis and anti/prooxidant activity and cytotoxicity studies of novel Sn and Au organometallic/coordination compounds are presented and discussed. The biological activity has been studied in in vitro, ex vivo, in vivo experiments in lipid peroxidation and mitochondria-associated processes, by using neurons, liver homogenates and in enzymatic reactions (xanthine oxidase, lipoxygenase, gluthathione reductase, thioredoxine reductase). Thus, we can conclude that the combination of two physiologically active moieties in a complex molecule is a promising approach to find the novel hybrid therapeutic agents with opposed biological mode of action.