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Solution NMR structures of beta-proline alternating homooligomersтезисы доклада
- Авторы: Mantsyzov A.B., Ivantcova P.M., Kudryavtsev K.V., Polshakov V.I.
- Сборник: Сборник тезисов VI Всероссийской конференции «Новые достижения ЯМР в структурных исследованиях»
- Тезисы
- Год издания: 2015
- Место издания: Издательство Казанского университета Казань
- Первая страница: 144
- Последняя страница: 145
- Аннотация: It has been demonstrated that beta-peptides can adopt stable conformations resemble those of natural peptides, however, difference in the structure of the main chain chiral centers makes beta-peptides inherently resistant to the proteolysis mediated by natural enzymes. These peculiar properties of beta-peptide molecules turn it to be very attractive objects for the drug design. Recently novel beta-proline homooligomers made of 5-phenylpyrrolidine-2,4-dicarboxylate monomeric units has been synthesized. Steric control over the cycloaddition reaction allowed to synthesize well-defined oligomers with a distinct alteration of pyrrolidine ring stereogenic centers between adjacent monomeric units. Here we present a solution-NMR study of the novel beta-proline oligomers. Installation of the bulky phenyl ring at C-alpha position and the ester group at C-delta results in formation of several conformers differing due to the peptide bonds isomerization. Sufficient number of collected NMR-derived constraints allowed us to determine high-resolution structures for the observed conformers for tetramer A and pentamer B. Anticancer activity against hormone-refractory prostate cancer cell line PC-3 was demonstrated for some alternating beta-peptides of type A and B, that rationalizes detailed structural studies for bioactivity enhancement.
- Добавил в систему: Польшаков Владимир Иванович