|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Age-Related Changes in the Rat Lacrimal Gland:Impressive Morphology and Enigmatic Natureстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 апреля 2015 г.
- Авторы: Gancharova O.S., Manskikh V.N.
- Журнал: Russian Journal of Developmental Biology
- Том: 45
- Номер: 5
- Год издания: 2014
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 235
- Последняя страница: 242
- DOI: 10.1134/S1062360414050051
- Аннотация: The rat lacrimal apparatus includes several glands; among them, the exorbital lacrimal gland plays the central role. Its parenchyma and stroma undergo prominent morphologic changes with age. The paren chymal transformation includes metaplasia of some of its acini and their turning into Harderian glandlike structures (harderization), accumulation of gland ducts (“ductularization”), and morphologic dysplasia— cytomegaly, karyomegaly, and cell and nuclear polymorphism in the other part of acini. All these transforma tions are hormonedependent and sexspecific: they more often appear in males. On the final stages of age related transformations, the lacrimal gland tissue is morphologically similar to a neoplasm and has neoplastic morphology but no other features of a tumor. Therefore, the rat lacrimal gland is an interesting object to study tissue and cell atypia. In the rat glandular stroma, lymphocytic infiltration and fibrosis appear with age; these changes are similar to processes taking place in human lacrimal apparatus involved in the pathogenesis of senile dry eye syndrome. The spontaneous changes in the rat lacrimal gland, predominantly in male rats, can be used as a model of the human lacrimal apparatus disorders.
- Добавил в систему: Скорикова Елена Евгеньевна