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NMR elucidation of molecular structure of the appetite receptor from Hoodia Gordoniiстатья
- Авторы: Shestakova A.K., Chertkov V.A.
- Журнал: EUROMAR-2011 Magnetic Resonance Conference, Frankfurt, 2011
- Год издания: 2011
- Аннотация: A plant Hoodia Gordonii is nowadays regarded as a source of biologically active compounds of natural origin with appetite-suppressant effect. In a series of first publications interdependency of the biological activity of the extracts with the presence of a steroid-based compound of the pregnene series was postulated, and structure of few compound was elucidated by a variety of insrumental techniques. Here we present results of detailed NMR study of major component of the alcohol extracts from Hoodia Gordonii. The structure was elucidated using the whole set of appropriate 1D and 2D NMR techniques: (3β,20S)-20-{[6-O-(6-O--D-glycero-hexopyranosyl-β-D-glycero-hexopyranosyl)-β-D-glycero-hexopyranosyl]oxy}-14-hydroxypregn-5-en-3-yl 2,6-dideoxy-4-O-{6-deoxy-2-O-methyl-4-O-[(2E)-2-methyl-2-butenoyl]-β-L-erythro-hexopyranosyl}-3-O-methyl-β-L-erythro-hexopyranoside.
- Добавил в систему: Чертков Вячеслав Алексеевич