Действие оксакома на давление в правом желудочке у крыс с легочной артериальной гипертензией, индуцированной монокроталином

Абрамов, А.А.; Лакомкин, В.Л.; Тимошин, А.А.; Лукошкова, Е.В.; Ермишкин, В.В.; Капелько, В.И.

Авторы: Абрамов А.А., Лакомкин В.Л., Тимошин А.А., Лукошкова Е.В., Ермишкин В.В., Капелько В.И.
Журнал: Артериальная гипертензия
Том: 23
Номер: 5
Год издания: 2017
Издательство: Общероссийская общественная организация "Содействия профилактике и лечению артериальной гипертензии "Антигипертензивная лига"
Местоположение издательства: Санкт-Петербург
Первая страница: 412
Последняя страница: 420
DOI: 10.18705/1607-419X-2017-23-5-412-420
Аннотация: Background. Pulmonary arterial hypertension (PAH) is a relatively rare disease, but its therapy is expensive and effectiveness is moderate. One of important mechanisms of PAH pathogenesis is reduced formation of nitric oxide in pulmonary vascular endotheliocytes. Objective. To study the effect of oxacom (dinitrosyle iron complex with ligand glutathione), which already demonstrated long-term decline in blood pressure (BP) in systemic circulation, on pressure in pulmonary circulation. Design and method. To induce PAH, the standard monocrotalin rat model was used. Three weeks after monocrotalin introduction (60 mg/kg), a catheterization of the right ventricle was performed in anesthetized rats (100 mg/kg ketamine) through jugular vein and pressure was measured. Simultaneously, BP in femoral artery and ECG were recorded. Results. Systolic pressure in the right ventricle (SPRV) in rats after monocrotalin introduction doubled compared with the control group, from 35 to 70 mmHg, but myocardial contractility index fell by 28 %, also duration of QRS complex and the height of T-wave increased. Intravenous oxacom (40 mg/kg) quickly reduced SPRV by average of 12 б╠ 3 mmHg, and this level was maintained for an hour. This effect was absent in control rats. Similar BP changes in systemic circulation were observed in both groups. Inhalation of nitric oxide led to BP decrease only in animals with high level of SPRV. Inhalation of oxacom was ineffective. Conclusion. Oxacom is a promising substance for sustained pressure decline in the pulmonary circulation in PAH, but further investigations are needed for the development of a more suitable prolonged-action form of the drug.
Добавил в систему: Абрамов Александр Александрович

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Действие оксакома на давление в правом желудочке у крыс с легочной артериальной гипертензией, индуцированной монокроталиномстатья

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