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HORIZONS IN CANCER RESEARCH. VOLUME 72 2019, Название главы в книге: TRANSCRIPTION FACTORS AND CO-ACTIVATORS/CO-REPRESSORS OF TRANSCRIPTION: STRUCTURE-RELATED CANCER TREATMENTкнига
- Авторы: Shestakova E.A., Shematorova E.K., Doludin Y.V., Shpakovski G.V.
- Год издания: 2019
- Издательство: Nova Science Publishers, Inc.
- Местоположение издательства: United States
- Объём: 49 страниц (3,0 печатных листов)
- ISBN: 978-1-5361-5812-0
- Монография
- Академическое издание
- Аннотация: Regulation of gene expression depends on binding of transcription factors and co-activators/co-repressors to DNA in gene promoters. Many transcription factors and co-activators/co-repressors could function as oncogenes and tumor suppressors, therefore, being involved in cancer development. Epigenetic mechanisms including histone modifications, methylation of DNA, incorporation of histone variants, and non-coding RNAs play an important role in the control of gene expression. Epigenetic regulation is involved in expression of several tumor suppressors and oncogenes among which are BRCA1, a key DNA repair protein, and с-Myc, a very potent oncogene, respectively. Epigenetic mechanisms are now emerging targets for cancer therapy and many epigenetic modifiers including histone deacetylase inhibitors (HDACi) such as vorinostat/SAHA, belinostat, panabiostat, romidepsin, entinostat, and DNA demethylating agents such as 5-aza-deoxycytidine alone or in combinations with other anticancer drugs are approved or are in pre-clinical and clinical trials for tumor treatment. In addition, many DNA-binding drugs function as inhibitors of transcription factor-DNA complexes, and therefore, influence gene transcription. Among these factors it is worth to mention transcription factors of HOX family with oncogenic properties. In relation with this, compounds that can bind minor or major groove of DNA are widely used in cancer therapy as well. Taken together, transcription factor and chromatin structure-related aspects of cancer treatment will be the focus of this review. Keywords:transcription factors, tumor suppressors, oncogenes, BRCA1, c-Myc, HOX, epigenetic regulation, minor and major DNA grooves, cancer treatment
- Добавил в систему: Шестакова Елена Анатольевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Chapter 6 Transcription Factors and Co-Activators/ Co-Repressors of Transcription: Structure-Related Cancer Treatment, Еlena А. Shestakova, Еlena К. Shematorova, Yuri V. Doludin and George V. Shpakovski, pp 175-223 | Shestakova_et_al_Chapter_2019.pdf | 1,4 МБ | 19 сентября 2021 [ShestakovaEAn] |