Аннотация:To develop a methodology for assessing human capital based on the ecosystem approach, taking into account the new paradigm of socio-economic development of the society in the era of intelligent machines, and to test this methodology on the example of the ecosystem in the Yaroslavl region. The methodology for assessing the impact of human capital on the region’s investment attractiveness is based on methodological approaches proposed by the RF Ministry of Economic Development, the Agency for Strategic Initiatives, and the RAEX National Rating Agency. The authors propose to use the correlation-regression model to assess the relationship of investment attractiveness of the region and human capital. The volume of investments in fixed assets and the average annual number of employees were used as calculated indicators. On the basis of the correlation-regression model, the relationship of investment attractiveness of the region and human capital is established. As calculation indicators the volume of investments in fixed capital and the average annual number of employed people for the ecosystem of Yaroslavl region were used. It has been found that the high level of human capital affects the creation of a favorable business environment and is the basis for the development of ecosystems, including industrial ones. The results of the study, brought to the level of practical recommendations, which can be used by managers and specialists of executive authorities in developing strategies for the socio-economic development of the region. Features of functioning of socio-economic systems in the conditions of digitalization are defined. It is proposed to consider human capital as a tool for the formation of a qualitatively new techno and business environment along the entire value chain. Methodological approaches to assessing the impact of human capital on the investment attractiveness of the region have been developed.