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More than 30 years of intense research activity on this topic have brought major advances in the understanding and the clinical management of the fibrogenic process common to most chronic liver diseases. There are however many aspects that certainly deserve further attention. Our conference is dedicated to all the current key areas of research in liver fibrogenesis and will focus on a number of open issues requiring further scientific efforts. The role of genetic/epigenetic factors and of the immune system, and the reversibility of fibrosis and methodologies for the identification of more reliable targets for drug development will represent some of the hot topics to be covered. Young scientists are particularly encouraged to participate and will have the opportunity to present their original results during a dedicated session. The format is intended to generate active interactions and discussion between basic scientists and clinicians, and to foster future collaborative efforts to better understand the pathogenesis of tissue fibrosis in chronic liver disease. Ultimately, to improve patient management.