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The specificity of MRI and NMR spectroscopy methods for animal study is discussed. Special attention is given to the registration of signals from nuclei other than protons - 19F, 31P, 13C, and others. Considerable attention is given to hardware-methodical aspects - the specifics of the receiver coils, the requirements for receiving and transmitting paths, optimize the pulse sequence parameters, particularly with regard to 19F MRI.