The ability of inactivated vaccines based on far eastern TBEV strains to induce humoral immune response in originally seropositive and seronegative recipientsстатья
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Дата последнего поиска статьи во внешних источниках: 4 сентября 2019 г.
Аннотация:Tick‐borne encephalitis (TBE) remains one of the major public health concerns in
northern Eurasia, and its’ area is expanding. TBE virus (TBEV) includes three subtypes
and several monophyletic groups, cocirculating in Russia. Five inactivated vaccines
are used for TBE prophylaxis. The rising number of people subjected to vaccination
brings up the issue of the impact of individual recipient characteristics on vaccination
efficacy. The present work studies correlations among the vaccination scheme, sex,
age, body mass index (BMI), chronic diseases, postvaccinal reaction, pre‐existing anti‐
TBEV antibodies, and postvaccinal humoral immunity development. Sera were
collected during clinical trials in the TBEV Siberian subtype endemic area. Adult
recipients were vaccinated with Tick‐E‐Vac and EnceVir vaccines based on Far‐
Eastern TBEV strains. Vaccine ability to induce humoral immunity in different
categories of recipients was estimated by seroconversion rates and the percentage of
recipients with high neutralizing antibody titers (≥1:500). High immunogenicity of
vaccines based on Far‐Eastern TBEV strains in the TBEV Siberian subtype endemic
area in all groups of recipients was demonstrated. Impact of pre‐existing contact with
the virus and high BMI on humoral immune response development 14 days after the
first immunization was evidenced. Nevertheless, the difference was significantly less
pronounced 30 days after the first vaccination and undetectable after the
second one.