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Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin a in differentiated cellsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 августа 2021 г.
- Авторы: Kostopoulou Nikoleta, Bellou Sofia, Bagli Eleni, Markou Maria, Kostaras Eleftherios, Hyvönen Marko, Kalaidzidis Yiannis, Papadopoulos Angelos, Chalmantzi Varvara, Kyrkou Athena, Panopoulou Ekaterini, Fotsis Theodore, Murphy Carol
- Журнал: Journal of Cell Science
- Том: 134
- Номер: 13
- Год издания: 2021
- Издательство: The Company of Biologists Ltd.
- Местоположение издательства: United Kingdom
- Номер статьи: jcs246892
- DOI: 10.1242/jcs.246892
- Аннотация: Ligand–receptor complexes formed at the plasma membrane are internalised via various endocytic pathways that influence the ultimate signalling output by regulating the selection of interaction partners by the complex along the trafficking route. We report that, in differentiated cells, activin A–receptor complexes are internalised via clathrin-mediated endocytosis (CME) and macropinocytosis (MP), whereas in human embryonic stem cells (hESCs) internalisation occurs via CME. We further show that hESCs are devoid of MP, which becomes functional upon differentiation towards endothelial cells through mesoderm mediators. Our results reveal, for the first time, that MP is an internalisation route for activin A in differentiated cells, and that MP is not active in hESCs and is induced as cells differentiate.
- Добавил в систему: Калайдзидис Яннис Леонтьевич