Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patientsстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Авторы:
Filipenko M.L. ,
Os’kina N.A. ,
Oskorbin I.A. ,
Mishukova O.V. ,
Ovchinnikova L.K. ,
Gershtein E.S. ,
Kushlinskii N.E.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
163
Номер:
2
Год издания:
2017
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
250
Последняя страница:
254
DOI:
10.1007/s10517-017-3777-z
Аннотация:
The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110О±-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients. В© 2017, Springer Science+Business Media, LLC.
Добавил в систему:
Герштейн Елена Сергеевна