Regulatory Proteins of Epithelial-Mesenchymal Transition and Some Components of VEGF Signaling Pathway in Breast Cancerстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Авторы:
Scherbakov A.M. ,
Gershtein E.S. ,
Korotkova E.A. ,
Ovchinnikova L.K. ,
Ovsii O.G. ,
Ermilova V.D. ,
Gens G.P. ,
Kushlinskii N.E.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
160
Номер:
6
Год издания:
2016
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
802
Последняя страница:
806
DOI:
10.1007/s10517-016-3314-5
Аннотация:
Immunohistochemical method was used to assay for Snail family regulatory proteins of epithelial-mesenchymal transition, their NF-ОєB coactivator, and the components of VEGF signaling pathway (VEGF and its receptors VEGFR1 and VEGFR2) in 157 specimens of breast tumors. Most tumors did not express SNAI1, while 65% tumors demonstrated mid- or high-level SNAI2 expression. There were significant correlations between the expression of SNAI1, SNAI2, and their NF-ОєB co-activator. Correlation was also detected between expression of Snail and VEGFR1 protein families in the tumors. In addition, the study revealed tumoral co-expression of SNAI2 and VEGFR2. The data attest to coordinated activation of regulatory proteins of epithelial-mesenchymal transition and the major components of VEGF signaling pathway in breast tumors. В© 2016, Springer Science+Business Media New York.
Добавил в систему:
Герштейн Елена Сергеевна