Biosensing systems based on metal oxides nanoparticles and choline oxidase for environmental and biochemical monitoring of neurotoxicants

Kurochkin, I.; Gromova, M.; Dontsova, E.; Sigolaeva, L.; Eremenko, A.; Evtushenko, E.; Budashov, I.; Nesterova, E.; Grigorkevich, O.; Savilov, S.; Lunin, V.

Авторы: Kurochkin I., Gromova M., Dontsova E., Sigolaeva L., Eremenko A., Evtushenko E., Budashov I., Nesterova E., Grigorkevich O., Savilov S., Lunin V.
Сборник: Portable Chemical Sensors: Weapons Against Bioterrorism
Серия: NATO Science for Peace and Security Series A: Chemistry and Biology
Год издания: 2012
Место издания: Springer Science+Business Media B.V Amsterdam, Netherlands
Первая страница: 151
Последняя страница: 170
DOI: 10.1007/978-94-007-2872-1_8
Аннотация: In this study we investigated the effects of monovalent anions in the series F−, Cl−, Br−, I− on the sensitivity of the biosensor assembled from polycations and ChO via theirs layer-by-layer deposition on the surface of carbon electrodes (CE) coated with MnO2. The efficiency of gamma-phase-MnO2 nanoparticles, deposited on screen-printed electrodes, as a new transducer element of biosensing platforms, fabricated with “layer-by-layer” technology was demonstrated. The present report describes analytical possibilities of the biosensing platform. The hydrogen peroxide registration and subsequent application for neurotoxicants assay in the environmental field. The validation of peroxide-sensitive sensors, as a new transducer element based on MnO2 nanoparticles, for fabrication of choline oxidase biosensor has been done. The revealed analytical characteristics of the choline oxidase biosensor are perspective for highly-sensitive monitoring of cholinesterases and their inhibitors in medical, biological and environmental samples.
Добавил в систему: Курочкин Илья Николаевич

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Biosensing systems based on metal oxides nanoparticles and choline oxidase for environmental and biochemical monitoring of neurotoxicantsстатья

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