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Preparation of hydrophilic polymer incorporated Curcuminoid Nanoparticles for the enhancement of dissolution rateстатья
Дата последнего поиска статьи во внешних источниках: 12 июня 2024 г.
- Авторы: Seema, Srivastava Monika, Singh Munendra, Kumar Sandeep, Kakroo Sunanda, Savilov S.V.
- Журнал: High Technology Letters
- Том: 29
- Номер: 12
- Год издания: 2023
- Издательство: Kexue Chubaneshe/Science Press
- Местоположение издательства: China
- Первая страница: 580
- Последняя страница: 599
- Аннотация: Curcuminoid a natural polyphenol possess anticancer activity but its poor water solubility and degradation of this drug in alkaline medium restricts its application as anticancer drug. The invincible effect of drug can be achieved by reducing the size of drug particles. Fabrication of the drug particles to its corresponding nanoparticles can be one of the best solutions to reveal the excellent properties of drug. Herewith we are reporting the fabrication of curcuminoid nanoparticles and its complex with polymer (PVP) via Evaporative Precipitation of Nanosuspension (EPN) method. Characterization of these drug nanoparticlesand its complex with biocompatible polymer PVP have been done by advance characterizing techniques such as FT-IR, , Transmission electron microscopy (TEM), Differential scanning calorimetric (DSC) and dissolution testing followed by UV-Visible spectroscopy. Results of these characterizations have revealed that synthesized nano curcuminoid particles have shown potent dissolution rate and on complexation with PVP crystallinity of drug decrease with tremendous decrease in particle size as much improved dissolution rate and can further be exploited for the anticancer action of the drug.
- Добавил в систему: Савилов Сергей Вячеславович